Efficacy and Safety of Pharmacological Interventions for the Treatment of the Alcohol Withdrawal Syndrome

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Systematic Review

Source: The Cochrane Collaborative

Last Reviewed: June 2011

In this Cochrane systematic review, the Cochrane Collaborative found that, compared with placebo or antipsychotics, benzodiazepines protect against seizures in people with alcohol withdrawal syndrome. Researchers also found that benzodiazepines were potentially protective for many outcomes compared to antipsychotics. They noted that they couldn’t draw definite conclusions about the effectiveness and safety of benzodiazepines because of differences across trial interventions and outcomes.

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Amato, L., Minozzi, S. & Davoli, M. (2011). Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. Cochrane Database of Systematic Reviews, 2011 (6). DOI: 10.1002/14651858.CD008537.pub2.