The importance of seasonal influenza vaccine for health care workers and high risk groups has been well documented, yet health care worker (HCW) influenza vaccination rates have risen only minimally over the past 20 years and are far short of U.S. Department of Health and Human Services Healthy People 2020 goals whose target is a 90 percent vaccination rate. One of the fundamental tenets of health care is to care for patients while protecting ourselves from harm. Because HCWs work in an environment where frequent contact with infectious patients is routine, we are at risk for exposure to influenza with possible transmission to other patients, their families, and other HCWs. The situation calls for a review of attitudes and beliefs toward influenza vaccination with a focus on the successful strategies associated with increased HCW vaccination rates.