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U.S. Department of Health and Human Services Office of Disease Prevention and Health Promotion

Reduce overdose deaths involving synthetic opioids other than methadone — IVP‑22 Data

National Status: Getting worse

  
Learn more about our data release schedule

Most Recent Data:
14.3 deaths per 100,000 population (2024) *

National Target:
8.9 per 100,000  *

Desired Direction:
Decrease desired

National Baseline:
9.9 deaths per 100,000 population were caused by an overdose involving synthetic opioids other than methadone in 2018 *

* Age adjusted to the year 2000 standard population.

Disparities data are only available for some selections.

View CI in the chart by hovering over a data point.

View SE in the chart by hovering over a data point.

Confidence Interval (CI) not available Standard Error (SE) not available Confidence Interval (CI) and Standard Error (SE) are not available

Display data for:

Drug overdose deaths involving synthetic opioids, excluding methadone, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Total
9.9
CI 9.8 / 10.0
SE 0.057
11.4
CI 11.3 / 11.5
SE 0.061
17.8
CI 17.6 / 17.9
SE 0.076
21.8
CI 21.7 / 22.0
SE 0.084
22.7
CI 22.5 / 22.9
SE 0.085
22.2
CI 22.0 / 22.3
SE 0.084
14.3
CI 14.2 / 14.4
SE 0.067

Drug overdose deaths involving synthetic opioids, excluding methadone by Sex, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Male
14.2
CI 14.1 / 14.4
SE 0.097
16.6
CI 16.4 / 16.8
SE 0.104
25.9
CI 25.7 / 26.2
SE 0.130
31.4
CI 31.2 / 31.7
SE 0.141
32.9
CI 32.6 / 33.2
SE 0.144
32.4
CI 32.1 / 32.7
SE 0.143
20.6
CI 20.4 / 20.8
SE 0.113
Female
5.5
CI 5.4 / 5.7
SE 0.060
6.3
CI 6.2 / 6.4
SE 0.064
9.6
CI 9.4 / 9.8
SE 0.079
12.2
CI 12.0 / 12.3
SE 0.089
12.4
CI 12.2 / 12.5
SE 0.089
11.9
CI 11.7 / 12.1
SE 0.087
8.0
CI 7.9 / 8.2
SE 0.071

Drug overdose deaths involving synthetic opioids, excluding methadone by Race/Ethnicity, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
American Indian or Alaska Native only
4.4
CI 3.7 / 5.1
SE 0.330
6.7
CI 5.9 / 7.5
SE 0.404
13.4
CI 12.3 / 14.6
SE 0.570
20.9
CI 19.5 / 22.3
SE 0.706
26.7
CI 25.2 / 28.4
SE 0.801
28.5
CI 26.9 / 30.2
SE 0.821
19.3
CI 18.1 / 20.7
SE 0.661
Asian only
0.9
CI 0.8 / 1.0
SE 0.066
1.1
CI 1.0 / 1.3
SE 0.073
2.3
CI 2.1 / 2.5
SE 0.105
2.4
CI 2.2 / 2.6
SE 0.106
3.0
CI 2.8 / 3.2
SE 0.117
3.1
CI 2.9 / 3.3
SE 0.118
2.1
CI 1.9 / 2.3
SE 0.093
Native Hawaiian or Other Pacific Islander only
1.6
CI 0.8 / 3.0
SE 0.441
2.6
CI 1.6 / 4.1
SE 0.546
4.1
CI 2.9 / 5.9
SE 0.697
8.9
CI 7.0 / 11.3
SE 1.021
8.0
CI 6.2 / 10.2
SE 0.945
13.0
CI 10.8 / 15.7
SE 1.203
8.7
CI 6.9 / 10.9
SE 0.968
Black or African American only
10.8
CI 10.5 / 11.1
SE 0.158
14.0
CI 13.7 / 14.4
SE 0.180
23.2
CI 22.8 / 23.7
SE 0.230
30.3
CI 29.8 / 30.8
SE 0.261
33.7
CI 33.2 / 34.3
SE 0.274
35.0
CI 34.5 / 35.6
SE 0.278
21.0
CI 20.6 / 21.4
SE 0.213
White only
10.9
CI 10.8 / 11.1
SE 0.069
12.3
CI 12.2 / 12.5
SE 0.074
18.7
CI 18.5 / 18.9
SE 0.091
22.6
CI 22.4 / 22.8
SE 0.099
23.0
CI 22.8 / 23.2
SE 0.100
21.9
CI 21.7 / 22.1
SE 0.097
14.4
CI 14.3 / 14.6
SE 0.078
2 or more races
3.6
CI 3.1 / 4.1
SE 0.232
4.7
CI 4.2 / 5.3
SE 0.264
9.2
CI 8.5 / 9.9
SE 0.361
12.0
CI 11.2 / 12.9
SE 0.411
13.5
CI 12.7 / 14.4
SE 0.428
15.2
CI 14.3 / 16.2
SE 0.457
10.5
CI 9.8 / 11.3
SE 0.373
Hispanic or Latino
4.7
CI 4.5 / 4.9
SE 0.091
6.3
CI 6.1 / 6.5
SE 0.103
10.7
CI 10.4 / 10.9
SE 0.133
14.2
CI 13.9 / 14.5
SE 0.152
16.0
CI 15.7 / 16.4
SE 0.161
16.5
CI 16.2 / 16.8
SE 0.161
10.9
CI 10.6 / 11.1
SE 0.129
Not Hispanic or Latino
11.1
CI 11.0 / 11.2
SE 0.067
12.6
CI 12.4 / 12.7
SE 0.072
19.4
CI 19.2 / 19.5
SE 0.089
23.5
CI 23.3 / 23.7
SE 0.097
24.1
CI 23.9 / 24.3
SE 0.098
23.3
CI 23.1 / 23.5
SE 0.096
15.0
CI 14.8 / 15.1
SE 0.077
American Indian or Alaska Native only, not Hispanic or Latino
7.0
CI 6.0 / 8.2
SE 0.561
10.8
CI 9.4 / 12.2
SE 0.687
21.6
CI 19.7 / 23.6
SE 0.971
33.6
CI 31.3 / 36.0
SE 1.205
43.6
CI 41.0 / 46.5
SE 1.384
46.5
CI 43.8 / 49.4
SE 1.427
32.3
CI 30.0 / 34.7
SE 1.184
Asian only, not Hispanic or Latino
0.9
CI 0.8 / 1.0
SE 0.066
1.1
CI 0.9 / 1.2
SE 0.072
2.2
CI 2.0 / 2.4
SE 0.106
2.2
CI 2.0 / 2.5
SE 0.105
2.8
CI 2.6 / 3.1
SE 0.116
3.0
CI 2.8 / 3.2
SE 0.118
2.0
CI 1.8 / 2.2
SE 0.092
Native Hawaiian or Other Pacific Islander only, not Hispanic or Latino
DSU
1.8
CI 0.9 / 3.4
SE 0.530
4.5
CI 3.0 / 6.6
SE 0.845
8.9
CI 6.8 / 11.7
SE 1.190
7.7
CI 5.7 / 10.3
SE 1.087
14.1
CI 11.4 / 17.4
SE 1.466
9.9
CI 7.6 / 12.6
SE 1.200
Black or African American only, not Hispanic or Latino
11.2
CI 10.8 / 11.5
SE 0.166
14.4
CI 14.0 / 14.8
SE 0.188
24.1
CI 23.6 / 24.6
SE 0.243
31.4
CI 30.8 / 31.9
SE 0.274
34.7
CI 34.2 / 35.3
SE 0.288
36.1
CI 35.5 / 36.7
SE 0.292
21.5
CI 21.1 / 22.0
SE 0.223
White only, not Hispanic or Latino
12.7
CI 12.6 / 12.9
SE 0.086
14.0
CI 13.8 / 14.2
SE 0.090
20.9
CI 20.7 / 21.1
SE 0.110
24.8
CI 24.6 / 25.1
SE 0.119
24.7
CI 24.5 / 25.0
SE 0.119
23.2
CI 23.0 / 23.4
SE 0.115
15.3
CI 15.1 / 15.4
SE 0.093
2 or more races, not Hispanic or Latino
4.0
CI 3.5 / 4.6
SE 0.278
5.1
CI 4.5 / 5.8
SE 0.310
9.8
CI 9.0 / 10.7
SE 0.424
13.1
CI 12.2 / 14.1
SE 0.490
14.7
CI 13.7 / 15.7
SE 0.508
16.1
CI 15.1 / 17.2
SE 0.535
11.5
CI 10.6 / 12.4
SE 0.446

Drug overdose deaths involving synthetic opioids, excluding methadone by Age group, 2018-2024 †
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
<18 years
0.1
CI 0.1 / 0.2
SE 0.014
0.2
CI 0.2 / 0.3
SE 0.018
0.6
CI 0.5 / 0.6
SE 0.028
0.8
CI 0.8 / 0.9
SE 0.034
1.0
CI 0.9 / 1.1
SE 0.037
1.1
CI 1.0 / 1.1
SE 0.038
0.5
CI 0.5 / 0.6
SE 0.027
0-4 years
0.1
CI 0.1 / 0.1
SE 0.022
0.2
CI 0.1 / 0.3
SE 0.032
0.3
CI 0.2 / 0.4
SE 0.040
0.7
CI 0.6 / 0.8
SE 0.061
1.0
CI 0.8 / 1.1
SE 0.073
1.1
CI 1.0 / 1.3
SE 0.078
0.7
CI 0.6 / 0.9
SE 0.063
5-11 years
DSU
DSU
DSU
0.0
CI 0.0 / 0.1
SE 0.013
0.1
CI 0.0 / 0.1
SE 0.016
0.1
CI 0.0 / 0.1
SE 0.015
0.0
CI 0.0 / 0.1
SE 0.012
12-17 years
0.3
CI 0.3 / 0.4
SE 0.036
0.5
CI 0.4 / 0.6
SE 0.045
1.4
CI 1.3 / 1.6
SE 0.075
1.8
CI 1.7 / 2.0
SE 0.084
2.0
CI 1.9 / 2.2
SE 0.089
2.1
CI 1.9 / 2.3
SE 0.089
1.0
CI 0.8 / 1.1
SE 0.060
18-44 years
17.2
CI 17.0 / 17.4
SE 0.121
19.4
CI 19.2 / 19.7
SE 0.128
30.3
CI 30.0 / 30.6
SE 0.160
36.2
CI 35.9 / 36.6
SE 0.174
36.1
CI 35.8 / 36.5
SE 0.173
34.3
CI 34.0 / 34.7
SE 0.169
21.6
CI 21.3 / 21.8
SE 0.132
18-24 years
8.4
CI 8.1 / 8.8
SE 0.166
9.7
CI 9.3 / 10.0
SE 0.179
16.9
CI 16.4 / 17.4
SE 0.237
18.3
CI 17.8 / 18.8
SE 0.247
15.8
CI 15.4 / 16.2
SE 0.225
14.1
CI 13.6 / 14.5
SE 0.214
8.1
CI 7.7 / 8.4
SE 0.160
25-44 years
20.3
CI 20.0 / 20.6
SE 0.153
22.8
CI 22.5 / 23.1
SE 0.161
34.9
CI 34.5 / 35.3
SE 0.199
42.3
CI 41.9 / 42.7
SE 0.218
43.3
CI 42.8 / 43.7
SE 0.220
41.2
CI 40.8 / 41.6
SE 0.214
26.2
CI 25.8 / 26.5
SE 0.169
45-64 years
12.1
CI 11.9 / 12.3
SE 0.120
14.6
CI 14.4 / 14.9
SE 0.132
22.4
CI 22.0 / 22.7
SE 0.164
29.1
CI 28.7 / 29.4
SE 0.187
31.8
CI 31.4 / 32.2
SE 0.196
32.3
CI 31.9 / 32.7
SE 0.198
21.4
CI 21.1 / 21.7
SE 0.161
45-54 years
14.7
CI 14.4 / 15.1
SE 0.188
17.3
CI 16.9 / 17.7
SE 0.206
26.6
CI 26.1 / 27.1
SE 0.257
33.1
CI 32.5 / 33.7
SE 0.285
35.6
CI 35.0 / 36.2
SE 0.297
35.5
CI 35.0 / 36.1
SE 0.296
23.7
CI 23.3 / 24.2
SE 0.241
55-64 years
9.5
CI 9.2 / 9.8
SE 0.150
12.0
CI 11.7 / 12.3
SE 0.168
18.3
CI 17.9 / 18.8
SE 0.208
25.2
CI 24.7 / 25.7
SE 0.243
28.1
CI 27.6 / 28.6
SE 0.259
29.2
CI 28.7 / 29.7
SE 0.264
19.2
CI 18.7 / 19.6
SE 0.214
65 years and over
1.7
CI 1.6 / 1.8
SE 0.056
2.1
CI 2.0 / 2.2
SE 0.062
3.1
CI 3.0 / 3.3
SE 0.075
4.7
CI 4.5 / 4.9
SE 0.092
5.8
CI 5.6 / 6.0
SE 0.100
6.8
CI 6.6 / 7.0
SE 0.107
5.0
CI 4.9 / 5.2
SE 0.091
65-74 years
2.6
CI 2.4 / 2.8
SE 0.092
3.3
CI 3.1 / 3.5
SE 0.103
5.0
CI 4.7 / 5.2
SE 0.124
7.3
CI 7.0 / 7.6
SE 0.147
9.2
CI 8.9 / 9.5
SE 0.165
10.8
CI 10.4 / 11.1
SE 0.176
8.0
CI 7.7 / 8.3
SE 0.150
75-84 years
0.4
CI 0.3 / 0.5
SE 0.051
0.5
CI 0.4 / 0.6
SE 0.054
0.6
CI 0.5 / 0.8
SE 0.062
0.9
CI 0.8 / 1.1
SE 0.075
1.2
CI 1.0 / 1.4
SE 0.082
1.5
CI 1.3 / 1.7
SE 0.091
1.2
CI 1.0 / 1.3
SE 0.078
85 years and over
0.3
CI 0.2 / 0.4
SE 0.065
0.2
CI 0.1 / 0.3
SE 0.048
0.2
CI 0.1 / 0.4
SE 0.060
0.4
CI 0.2 / 0.6
SE 0.078
0.2
CI 0.1 / 0.4
SE 0.062
0.3
CI 0.2 / 0.5
SE 0.072
0.3
CI 0.2 / 0.5
SE 0.071

Drug overdose deaths involving synthetic opioids, excluding methadone by Educational attainment (25-64 years), 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Educational attainment (25-64 years)
DNA
DNA
DNA
DNA
DNA
DNA
DNA

Drug overdose deaths involving synthetic opioids, excluding methadone by Family income, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Family income
DNC
DNC
DNC
DNC
DNC
DNC
DNC

Drug overdose deaths involving synthetic opioids, excluding methadone by Health insurance status, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Health insurance status
DNC
DNC
DNC
DNC
DNC
DNC
DNC

Drug overdose deaths involving synthetic opioids, excluding methadone by Geographic location, 2018-2024 *  1
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Metropolitan
10.3
CI 10.2 / 10.5
SE 0.062
11.9
CI 11.8 / 12.0
SE 0.067
18.3
CI 18.1 / 18.5
SE 0.083
22.2
CI 22.1 / 22.4
SE 0.090
DNA
DNA
DNA
Non-metropolitan
7.1
CI 6.8 / 7.4
SE 0.136
8.3
CI 8.0 / 8.6
SE 0.147
14.3
CI 14.0 / 14.7
SE 0.193
19.4
CI 19.0 / 19.9
SE 0.224
DNA
DNA
DNA

Drug overdose deaths involving synthetic opioids, excluding methadone by Marital status (25 years and over), 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Marital status (25 years and over)
DNA
DNA
DNA
DNA
DNA
DNA
DNA

Drug overdose deaths involving synthetic opioids, excluding methadone by Country of birth, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Country of birth
DNA
DNA
DNA
DNA
DNA
DNA
DNA

Drug overdose deaths involving synthetic opioids, excluding methadone by Veteran status, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Veteran status
DNC
DNC
DNC
DNC
DNC
DNC
DNC

Drug overdose deaths involving synthetic opioids, excluding methadone by Disability status, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Disability status
DNC
DNC
DNC
DNC
DNC
DNC
DNC

Drug overdose deaths involving synthetic opioids, excluding methadone by Sexual orientation, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Sexual orientation
DNC
DNC
DNC
DNC
DNC
DNC
DNC

Drug overdose deaths involving synthetic opioids, excluding methadone by Gender identity, 2018-2024 *
(deaths per 100,000 population)
Decrease desired

Population 2018 2019 2020 2021 2022 2023 2024
Gender identity
DNC
DNC
DNC
DNC
DNC
DNC
DNC

Disparity